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CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO
《农业科学与工程前沿（英文）》 2021年 第8卷 第2期
Electrical signals commonly occur in plants in response to various environmental changes and have a dominant function in plant acclimation. The transduction of wound-elicited electrical signals in the model plant species Arabidopsis has been characterized but the characteristics of electrical signal transduction in response to herbivory or wounding in crop species remain unknown. Here, the features of electrical signals elicited by insect herbivory and wounding in tomato were investigated. Unlike those in Arabidopsis, wounding tomato leaves did not cause leaf-to-leaf electrical signal transduction. In contrast, electrical signals elicited in response to petiole wounding were stronger and more strongly transduced. Leaflet wounding also activated electrical signal transduction and jasmonic acid (JA) signaling within the whole compound leaf. It was also demonstrated that tomato glutamate receptor-like 3.3 (GLR3.3) and GLR3.5 mediated leaflet-to-leaflet electrical signal transduction. Herbivory-induced JA accumulation and Helicoverpa armigera resistance were reduced in glr3.3/3.5 plants. This work reveals the nature of electrical signal transduction in tomato and emphasizes the key roles of GLR3.3 and GLR3.5 in electrical signal transduction and JA signaling activation.
关键词： electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
《医学前沿（英文）》 2021年 第15卷 第2期 页码 292-301 doi: 10.1007/s11684-020-0806-5
关键词： bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
null
《医学前沿（英文）》 2015年 第9卷 第3期 页码 288-303 doi: 10.1007/s11684-015-0412-0
Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self-renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.
关键词： TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
《医学前沿（英文）》 2020年 第14卷 第1期 页码 81-90 doi: 10.1007/s11684-019-0692-x
关键词： soluble C-type lectin-like receptor-2 coronary artery disease risk factor
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
《医学前沿（英文）》 2010年 第4卷 第2期 页码 225-228 doi: 10.1007/s11684-010-0003-z
关键词： bradykinin vascular smooth muscle cells signal transduction pathways
《环境科学与工程前沿（英文）》 2023年 第18卷 第4期 doi: 10.1007/s11783-024-1804-7
● Cu-C-MSNs are developed via a co-doping step of Cu with L(+)-ascorbic acid.
关键词： Cation-π structures Polarization electric field Fenton-like process Contaminants cleavage
假单胞菌环状脂肽Medpeptin的生物合成及其调控植物免疫的作用机制 Article
谷医林, 李俊州, 李彦, 从珅, 王静, 马毅楠, 魏海雷
《工程（英文）》 2023年 第28卷 第9期 页码 153-165 doi: 10.1016/j.eng.2023.05.016
环状脂肽（cyclic lipopeptides, CLP）是一类由细菌产生的多功能次生代谢产物，也是一类重要的植物免疫激发子。假单胞菌环状脂肽在结构和生物活性上极其复杂和多样化。但是，目前对环状脂肽的结构及其与植物互作中的功能认识仍比较有限。本研究从地中海假单胞菌中鉴定了一种由22个氨基酸组成的新型的环状脂肽medpeptin，该脂肽由一个非核糖体肽合成酶基因簇合成并受群体感应系统调节。进一步研究发现，medpeptin可以诱导植物产生免疫反应，增强植物对病原细菌的抗性，但其自身不具备抗菌活性。利用比较转录组分析和病毒诱导的基因沉默技术解析了参与medpeptin感知植物免疫信号候选关键基因。结果显示，当沉默本氏烟中细胞壁富含亮氨酸的重复延伸蛋白NbLRX3或类受体蛋白激酶NbRLK25后，medpepatin触发的细胞死亡和对病原细菌的抗性受到严重影响，而沉默BAK1或SGT1则并未影响这一表型。本研究结果揭示了一种非典型的CLP感知机制，并为植物抗病免疫研究提供了新的借鉴。
关键词： 假单胞菌 环状脂肽 细胞死亡 富含异亮氨酸的延伸蛋白 类受体激酶
Group III metabotropic glutamate receptors and drug addiction
null
《医学前沿（英文）》 2013年 第7卷 第4期 页码 445-451 doi: 10.1007/s11684-013-0291-1
Neuroadaptations of glutamatergic transmission in the limbic reward circuitry are linked to persistent drug addiction. Accumulating data have demonstrated roles of ionotropic glutamate receptors and group I and II metabotropic glutamate receptors (mGluRs) in this event. Emerging evidence also identifies Gαi/o-coupled group III mGluRs (mGluR4/7/8 subtypes enriched in the limbic system) as direct substrates of drugs of abuse and active regulators of drug action. Auto- and heteroreceptors of mGluR4/7/8 reside predominantly on nerve terminals of glutamatergic corticostriatal and GABAergic striatopallidal pathways, respectively. These presynaptic receptors regulate basal and/or phasic release of respective transmitters to maintain basal ganglia homeostasis. In response to operant administration of common addictive drugs, such as psychostimulants (cocaine and amphetamine), alcohol and opiates, limbic group III mGluRs undergo drastic adaptations to contribute to the enduring remodeling of excitatory synapses and to usually suppress drug seeking behavior. As a result, a loss-of-function mutation (knockout) of individual group III receptor subtypes often promotes drug seeking. This review summarizes the data from recent studies on three group III receptor subtypes (mGluR4/7/8) expressed in the basal ganglia and analyzes their roles in the regulation of dopamine and glutamate signaling in the striatum and their participation in the addictive properties of three major classes of drugs (psychostimulants, alcohol, and opiates).
关键词： group III metabotropic glutamate receptors cocaine amphetamine alcohol opiate
《农业科学与工程前沿（英文）》 2021年 第8卷 第2期
D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plants that operate under adverse conditions. Here, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1 protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and high light conditions (HH, 35°C, 1000 µmol·m-2·s-1). SM and DTT treatments significantly reduced the net photosynthetic rate, apparent quantum efficiency, maximum photochemical efficiency, and potential activity of photosystem II, leading to photoinhibition and a decline in plant biomass under HH. The increase in reactive oxygen species levels resulted in thylakoid membrane lipid peroxidation. In addition, there were increased non-photochemical quenching and decreased chlorophyll pigments in SM and DTT application, causing an inhibition of D1 protein production at both transcriptional and translational levels. Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition. Additionally, the recovery levels of most photosynthesis indicators in DTT-treated plants were higher than in SM-treated plants. These findings support the view that D1 turnover has a more important role than XC in photoprotection in tomato under HH conditions.
关键词： D1 turnover / photoinhibition / photoprotection / photosynthesis / tomato / xanthophyll cycle
LIU Rui, ZHOU Qixing, ZHANG Lanying, GUO Hao
《环境科学与工程前沿（英文）》 2007年 第1卷 第1期 页码 114-119 doi: 10.1007/s11783-007-0021-5
关键词： monosodium glutamate different inhibitory pollution exposure half-effect
《化学科学与工程前沿（英文）》 2023年 第17卷 第6期 页码 704-715 doi: 10.1007/s11705-022-2270-z
关键词： bio-based multifunction colorimetric indicator active and intelligent packaging
PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (
Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI
《农业科学与工程前沿（英文）》 页码 262-279 doi: 10.15302/J-FASE-2021383
关键词： D1 turnover photoinhibition photoprotection photosynthesis tomato xanthophyll cycle
《农业科学与工程前沿（英文）》 2021年 第8卷 第2期
Fruit cracking is a major disorder that affects the integrity of fruit and reduces the commercial value of tomato and other fleshy fruit. Here, we have found a novel fruit ‘netted-cracking’ (FNC) phenotype in tomato introgression line IL4-4 which is present in neither the donor parent (LA0716) nor the receptor parent (M82). An F2 population was generated by crossing IL4-4 with M82 to genetically characterize the FNC gene and this showed that a single dominant gene determined fruit netted-cracking. Further map-based cloning narrowed down the FNC locus to a 230 kb region on chromosome 4. Sequencing and annotation analysis show that FNC(Solyc04 g082540) was the most likely candidate gene. Functional characterization of FNC by overexpressing FNCAC and FNCIL4-4resulted in the fruit netted-cracking phenotype, suggesting that the FNC transcript level results in the functional gain of fruit netted-cracking. These findings were further confirmed by FNC ortholog in netted-cracking pepper and melon, indicating a common regulatory mechanism in different plant species. Furthermore, cytoplasm and nucleus-localized FNC indicates increased expression of genes involved in suberin, lignin, lipid transport and cell wall metabolism. These findings provide novel genetic insights into fruit netted-cracking and offer a way to promote molecular improvement toward cracking resistant cultivars.
关键词： fine mapping / fruit netted-cracking / introgression line / transcript level
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
《医学前沿（英文）》 2012年 第6卷 第1期 页码 35-40 doi: 10.1007/s11684-012-0171-0
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
关键词： α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
Recycling Materials from Waste Electrical and Electronic Equipment
Jinhui Li
《环境科学与工程前沿（英文）》 2017年 第11卷 第5期 doi: 10.1007/s11783-017-1001-z
标题 作者 时间 类型 操作
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via theToll-like receptor 4 signaling pathway
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
期刊论文
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
null
期刊论文
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
期刊论文
Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involvedsignal transduction pathways
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
期刊论文
Enhanced Fenton-like process over Cu/L(+)-ascorbic acid co-doping mesoporous silica for toxicity reduction
期刊论文
PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (SOLANUM LYCOPERSICUM) UNDER
期刊论文
Toxic effects of wastewater from various phases of monosodium glutamate production on seed germination
LIU Rui, ZHOU Qixing, ZHANG Lanying, GUO Hao
期刊论文
nano zinc oxide for active and intelligent packaging: comparison of anthocyanins source from purple tomato
期刊论文
PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (
Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI
期刊论文
FUNCTIONAL GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OF
期刊论文
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
期刊论文
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